Tracking the mechanisms of deep brain stimulation for neuropsychiatric disorders.

نویسندگان

  • J Luis Lujan
  • Ashutosh Chaturvedi
  • Cameron C McIntyre
چکیده

Deep brain stimulation (DBS) has recently emerged as a potential treatment for medically intractable neuropsychiatric disorders. Pilot clinical studies with encouraging results have been performed with DBS of the ventral anterior internal capsule (VAIC) and subgenual cingulate white matter (Cg25WM) for the treatment of obsessive-compulsive disorder and depression. However, little is known about the underlying response of individual neurons, or the networks they are connected to, when DBS is applied to the VAIC or Cg25WM. This review summarizes current understanding of the response of axons to DBS, and discusses the general brain network architectures thought to underlie neuropsychiatric disorders. We also employ diffusion tensor imaging tractography to better understand the axonal trajectories surrounding DBS electrodes implanted in the VAIC or Cg25WM. Finally, we attempt to reconcile various data sets by presenting generalized hypotheses on potential therapeutic mechanisms of DBS for neuropsychiatric disease.

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عنوان ژورنال:
  • Frontiers in bioscience : a journal and virtual library

دوره 13  شماره 

صفحات  -

تاریخ انتشار 2008